The experience of newborn screening for Krabbe disease in New York State demonstrates the ethical problems that arise when screening programs are expanded in the absence of true understanding of the diseases involved. In its 5 years of testing and millions of dollars in costs, there have been very few benefits, and the testing has uncovered potential cases of late-onset disease that raise difficult ethical questions in their own right. For these reasons, we argue that Krabbe screening should only be (...) continued as a research project that includes the informed consent of parents to the testing. (shrink)

Fourth-year medical students at the University of Colorado School of Medicine distributed cards to patients in the emergency department asking, "What Worries You Most?" The patients' responses provided insight about their most pressing concerns, often unrelated to their "chief complaints.".

Although the social and economic structure of peasant households exhibited much continuity before and after the rise of capitalism, those households were not rigid or inflexible in the face of economic change. A study of peasants in a Dutch region shows that households, motivated and bound by both cultural and economic factors, made careful choices in how to react to capitalist pressures. By responding actively and deliberately, peasants were able to exert significant control over their lives and their future and (...) did not become mere victims of capitalist development. Indeed, instead they actually helped shape the local economy. (shrink)

When the first volume of the Oxyrhynchus Papyri was published in 1898, all lovers of Sappho must have been disappointed with the latter half of Blass's otherwise excellent restoration of this poem. The perusal of a recent article by J. Sitzler, in which later suggestions are discussed and fresh ones made, only serves to confirm this feeling of dissatisfaction. Sappho's extant work elsewhere combines a dignified simplicity of matter with a dignified simplicity of form. Any obscurity we find in it, (...) is due rather to our ignorance of her dialect than to any real strangeness of thought or diction. By simple ideas, simple constructions, simple words, she produces a beauty all her own. It must be confessed that the latter half of the Ode to the Nereids, as it stands in any of the published restorations falls short of all else of Sappho's that we possess. It is just possible that in line II ⋯τοισι can stand as a feminine, but, grammar apart, nothing, surely, could be tamer than the sentence as it stands with the long relative clause beginning in line 13—‘When he heard the reproach, which used to cut him to the quick and restrain him amid the mirth of his fellow citizens, and which died away for a time only to be revived soon after.’ I hope to bring the poem a stage nearer satisfactory restoration by showing that there are grounds for rejecting some at least of the suggestions which contribute to this result. (shrink)

Although generally not thought to be a work of political theory, 'The Record and Process of the Deposition of Richard II' was grounded in both practice and theory. A recitation of the political sins of Richard II, it also became a theoretical statement of what medieval Englishmen expected good kingship to be. It was grounded in the common law tradition as well as in the work of various fourteenth-century theorists. 'The Record and Process' enunciated specific rights that its authors expected (...) a king to observe as well as indicating that English kings were considered to be below both natural and positive law. (shrink)